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1018
HitGen Enters into DNA-Encoded Library Based Drug Discovery Research Collaboration with Galapagos NV
HitGen Enters into DNA-Encoded Library Based Drug Discovery Research Collaboration with Galapagos NVTHURSDAY, OCTOBER 17, 2019HitGen Inc. today announced that it has entered into a drug discovery research collaboration with Galapagos NV to identify potential small molecule leads against targets of interest to Galapagos NV. In this collaboration, HitGen will apply its technology platform, based on DNA-encoded library design, synthesis and interrogation, to discover novel leads. Under the terms of the agreement, HitGen will receive an undisclosed upfront payment and will be eligible for milestone payments from Galapagos NV.“We are delighted to enter this collaboration with Galapagos NV, a leading biotechnology company, specializing in the discovery and development of small molecule medicines with novel modes of action. We believe the collaboration reinforces the role of HitGen’s platform in the rapidly developing field of DNA-encoded chemistry. We will work closely with Galapagos NV scientists to generate new small-molecule lead compounds for their research programs to help bring transformative medicines to patients,” said Dr. Jin Li, Chairman of the Board and Chief Executive Officer of HitGen.“We look forward to working with HitGen and tap into their established DEL technology platform to complement our internal screening and drug discovery technologies.” said Romain Gosmini, Director Medicinal Chemistry at Galapagos.information source:pharma focus AsiaThe original link:https:https://www.pharmafocusasia.com/news/hitgen-enters-into-dna-encoded-library-based-drug-discovery-research-collaboration-with-galapagos-nv2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p/510934/ will be held in Beijing on November 14-15, and will attract more than 500 industry experts from domestic and foreign pharmaceutical companies, biotechnology companies, governments, associations, law firms, intellectual property agents and other companies to attend.Official registration and consultation channels:Contact：AnnPhone: 021-65650305Email：Marketing@zenseegroup.comhttp://en.zenseegroup.com/p/510934 -
1017
WindMIL Therapeutics and University of California, Irvine Announce Collaboration to Collect Bone Marrow from Patients with Gliomas
WindMIL Therapeutics and University of California, Irvine Announce Collaboration to Collect Bone Marrow from Patients with GliomasWEDNESDAY, OCTOBER 16, 2019WindMIL Therapeutics and the University of California, Irvine (UCI) today announced that the first patients have been identified in an investigator-sponsored study for the collection of bone marrow from patients with gliomas. The study will evaluate generating marrow infiltrating lymphocytes (MILs™) for these patients through WindMIL’s proprietary cellular activation and expansion process. The study is being conducted at UCI.“Patients suffering with glioblastoma are in great need of new, promising treatments that might advance the current standard of care,” said Daniela A. Bota, MD, PhD, director of the UCI Health Comprehensive Brain Tumor Program, senior associate dean for clinical research, UCI School of Medicine and clinical director, UCI Sue & Bill Gross Stem Cell Research Center. “The University of California, Irvine is excited to play a key role in research that may lead to a clinical trial that enlists the immune system in novel ways to fight this terrible disease.”Gliomas are the most common of the malignant brain tumors. Glioblastoma, the most common glioma, has a five-year survival of less than 5 percent. Additional treatment options are urgently needed for these patients. Adoptive immunotherapy is a possible approach for gliomas and the use of MILs, a cell therapy that is naturally tumor-specific, is one such treatment option.The bone marrow is a unique niche in the immune system to which antigen-experienced memory T cells traffic and are then maintained. WindMIL has developed a proprietary process to select, activate and expand these memory T cells into MILs. Because memory T cells in bone marrow occur as a result of the immune system’s recognition of tumor antigens, MILs are specifically suited for adoptive cellular immunotherapy and are able to directly eradicate or facilitate eradication of each patient’s unique cancer. WindMIL is currently studying MILs in multiple myeloma, non-small cell lung cancer and squamous cell carcinoma of the head and neck, and plans to expand into other solid tumors.“WindMIL is looking forward to working with the University of California, Irvine on this exciting project and is optimistic that MILs may offer the potential to help patients with these hard-to-treat diseases,” said Monil Shah, PharmD, MBA, Chief Development Officer at WindMIL.information source:pharma focus AsiaThe original link:https://www.pharmafocusasia.com/news/windmil-therapeutics-and-university-of-california-irvine-announce-collaboration-to-collect-bone-marrow-from-patients-with-gliomas2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p/510934/will be held in Beijing on November 14-15, and will attract more than 500 industry experts from domestic and foreign pharmaceutical companies, biotechnology companies, governments, associations, law firms, intellectual property agents and other companies to attend.Official registration and consultation channels:Contact：AnnPhone: 021-65650305Email：Marketing@zenseegroup.comhttp://en.zenseegroup.com/p/510934/ -
1016
CRISPR Therapeutics and KSQ Therapeutics Announce License Agreement to Advance Companies’ Respective Cell Therapy Programs in Oncology
CRISPR Therapeutics and KSQ Therapeutics Announce License Agreement to Advance Companies’ Respective Cell Therapy Programs in OncologyWEDNESDAY, OCTOBER 16, 2019CRISPR Therapeutics, a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, and KSQ Therapeutics, a biotechnology company using CRISPR technology to enable the company’s powerful drug discovery engine to achieve higher probabilities of success in drug development, today announced a license agreement whereby CRISPR Therapeutics will gain access to KSQ intellectual property (IP) for editing certain novel gene targets in its allogeneic oncology cell therapy programs, and KSQ will gain access to CRISPR Therapeutics’ IP for editing novel gene targets identified by KSQ as part of its current and future eTILTM (engineered tumor infiltrating lymphocyte) cell programs. The financial terms of the agreement are not being disclosed.“We are thrilled to gain access to CRISPR Therapeutics’ foundational IP estate through this agreement,” said David Meeker, M.D., Chief Executive Officer at KSQ Therapeutics. “Our eTILTM programs involve editing gene targets in human TILs that were discovered at KSQ by applying our proprietary CRISPRomics® approach to immune cells in multiple in vivo models. This agreement clears an important path for us to be able to bring these programs through development and commercialization, leveraging CRISPR Therapeutics’ proprietary editing technology.”The gene targets within the scope of the license agreement were identified using KSQ’s proprietary CRISPRomics® drug discovery engine, which allows genome-scale, in vivo validated, unbiased drug discovery. These specific targets were uncovered in screens to identify genetic edits that could enhance the functionality and quality of adoptive cell therapies in oncology.“KSQ has built an industry-leading platform to screen for novel gene targets using its technology, and has identified a group of targets that could help unlock the full potential of adoptive cell therapy in oncology,” said Samarth Kulkarni, Ph.D., Chief Executive Officer at CRISPR Therapeutics. “As a result of this license agreement, CRISPR Therapeutics will have the opportunity to bring these novel targets into our leading allogeneic CAR-T development platform to further strengthen our future programs in this important therapeutic area.”information source:pharma focus AsiaThe original link:https:https://www.pharmafocusasia.com/news/crispr-therapeutics-and-ksq-therapeutics-announce-license-agreement-to-advance-companies-respective-cell-therapy-programs-in-oncology2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p/510934/ will be held in Beijing on November 14-15, and will attract more than 500 industry experts from domestic and foreign pharmaceutical companies, biotechnology companies, governments, associations, law firms, intellectual property agents and other companies to attend.Official registration and consultation channels:Contact：AnnPhone: 021-65650305Email：Marketing@zenseegroup.comhttp://en.zenseegroup.com/p/510934/ -
1015
Shionogi enters into a new license agreement and research collaboration for the treatment of mycobacterial diseases with Hsiri Therapeutics, Inc.
Shionogi enters into a new license agreement and research collaboration for the treatment of mycobacterial diseases with Hsiri Therapeutics, Inc.MONDAY, OCTOBER 14, 2019Shionogi & Co., Ltd. today announced that it has entered into a new license agreement with Hsiri Therapeutics, Inc. (Head Office: Media, PA, USA; President and CEO: William Claypool, M.D.; hereafter "Hsiri") regarding a collaborative research and development program to discover and develop additional novel therapeutics for non-tuberculous mycobacterial (NTM) diseases and tuberculosis (TB). This new collaboration will include technology that complements Shionogi's earlier collaboration arrangement with Hsiri.The new technology to be licensed from Hsiri has a novel mechanism of action, will be complementary to Shionogi's current research with Hsiri, and is anticipated to be more effective than current therapies for mycobacterial infections. Shionogi's strength in small molecule drug discovery and development in the antibacterial area will support development of Hsiri's innovative therapeutics in this collaborative program. Under the terms of this agreement, Shionogi will have exclusive worldwide rights to develop, manufacture, and commercialize the compounds generated from the collaboration. Hsiri will receive an upfront license fee, potential development milestones, and royalty payments based on sales from Shionogi.It is reported that the number of patients suffering from NTM diseases has been increasing, especially in developed countries, in recent years. There is a medical need to develop novel anti-NTM drugs because of the long duration of treatment and insufficient treatment outcome of current therapeutics. TB is one of the three major infectious diseases in the world, and new cases of TB are estimated to be 10.4 million/year. Multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) have become a major public health concern, and novel drugs for MDR-TB and XDR-TB are anticipated.Shionogi's research and development targets infectious disease as one of its priority areas, and Shionogi have positioned "protecting people from the threat of infectious diseases" as one of its social mission targets. Through this cooperation, Shionogi strives constantly to bring forth innovative drugs for the treatment of infectious diseases, to protect the health of patients we serve.information source:pharma focus AsiaThe original link:https:https:https://www.pharmafocusasia.com/news/shionogi-enters-into-a-new-license-agreement-and-research-collaboration-for-the-treatment-of-mycobacterial-diseases-with-hsiri-therapeutics-inc2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p/510934/ will be held in Beijing on November 14-15, and will attract more than 500 industry experts from domestic and foreign pharmaceutical companies, biotechnology companies, governments, associations, law firms, intellectual property agents and other companies to attend.Official registration and consultation channels:Contact：AnnPhone: 021-65650305Email：Marketing@zenseegroup.comhttp://en.zenseegroup.com/p/510934/ -
1014
Advaxis and UCLA Enter Collaboration for Glioblastoma Immunotherapy Discovery Research
Advaxis and UCLA Enter Collaboration for Glioblastoma Immunotherapy Discovery ResearchFRIDAY, OCTOBER 11, 2019Advaxis, Inc., a clinical-stage biotechnology company focused on the discovery, development and commercialization of immunotherapy products, today announced a research collaboration agreement with the University of California Los Angeles (UCLA) to conduct preclinical studies evaluating the Company’s Lm technology in mouse tumor models of glioblastoma multiforme (GBM). Specifically, the collaboration with Dr. Vaithi Arumugaswami’s group at UCLA’s Department of Molecular and Medical Pharmacology will investigate anti-tumor immunity and anti-tumor responses generated by Lm vaccines that express diverse glioblastoma neoantigens.“We are excited that Dr. Arumugaswami and his colleagues at UCLA will investigate the potential of our Lm technology platform in GBM, one of the deadliest cancers,” said Andres Gutierrez, Executive Vice President and Chief Medical Officer of Advaxis. “Contrary to other tumor types, GBM has not seen much success in targeting by immunotherapeutic agents due to a low tumor mutation burden, high tumor heterogeneity and presence of the blood brain barrier, among other factors. Hence, Dr. Arumugaswami’s characterization of the neoantigen landscape and immune responses to Lm- constructs may lead to the development of novel therapies with clinical activity in this elusive cancer.”information source:pharma focus AsiaThe original link:https:https:https://www.pharmafocusasia.com/news/advaxis-and-ucla-enter-collaboration-for-glioblastoma-immunotherapy-discovery-research2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p/510934/will be held in Beijing on November 14-15, and will attract more than 500 industry experts from domestic and foreign pharmaceutical companies, biotechnology companies, governments, associations, law firms, intellectual property agents and other companies to attend.Official registration and consultation channels:Contact：AnnPhone: 021-65650305Email：Marketing@zenseegroup.comhttp://en.zenseegroup.com/p/510934/
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