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0927
NeuCyte Licenses Promising Novel Compound for Treatment of Refractory Epilepsy and Related Neurological Disorders
NeuCyte, Inc., an innovative biotech company focused on developing novel treatments for neurological disorders, today announced that it has entered into an exclusive license agreement with Trillium Therapeutics to advance an undisclosed preclinical compound with potential utility in treating refractory epilepsy in the form of Dravet syndrome and related disorders.The compound covered by this agreement has demonstrated highly encouraging activity during studies conducted by the National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP). It demonstrates a superior safety and anti-seizure efficacy profile over NINDS benchmark anti-epileptic drugs (AEDs) in eleven animal models. It has also demonstrated broad efficacy in NIH animal studies for pharmaco-resistant epilepsy. As a result, this novel agent has gained the prestigious NINDS Red Book status and been selected as a promising lead drug candidate."This compound is an exceedingly promising antiseizure drug which, although in preclinical development, is quite efficacious in a wide variety of highly predictive seizure models," said Roger J. Porter, MD, Adjunct Professor of Neurology at the University of Pennsylvania, former Deputy Director of NINDS, former Chairman of the White House Committee on Brain and Behavioral Sciences, and former President of American Epilepsy Society. "It may prove very effective for patients with epilepsy." As a first-in-class compound with unique mechanism of action profiles, this drug candidate is likely to have activity across a variety of indications. The favorable efficacy and safety profile has also been validated by NeuCyte's proprietary in vitro human iPSC-derived models."Epilepsy is the fourth most common neurological disease affecting more than 65 million people of all ages worldwide. The complex and multifactorial nature of the disorders makes treatment complicated and challenging. Up to 40% of newly diagnosed epilepsy patients are resistant to current therapies which highlights the urgent need to develop first-in-class treatments," said Jacqueline A. French, MD, Chief Medical and Innovation Officer of the Epilepsy Foundation and epileptologist in New York City. "It is very encouraging to see new developments and therapeutic candidates in this disease area."Under the terms of the agreement, Trillium has granted NeuCyte exclusive, worldwide rights to develop and commercialize the compound. "NeuCyte is committed to bringing breakthrough therapies to epilepsy patients and believe that our advantageous translational technology platform and CNS expertise enable us to optimally advance such therapeutic candidates," said Tao Huang, PhD, JD, President and Chief Executive Officer of NeuCyte. "This licensing agreement allows us to expand our pipeline and advance our goal of meeting unmet clinical needs and truly improving patient care and quality of life."information source:pharma focus AsiaThe original link:https:https:https://www.pharmafocusasia.com/news/neucyte-licenses-promising-novel-compound-for-treatment-of-refractory-epilepsy-and-related-neurological-disorders2019 Asia-pacific pharma IP Leader Summit:http://en.zenseegroup.com/p/510934/will be held in Beijing on November 14-15, and will attract more than 500 industry experts from domestic and foreign pharmaceutical companies, biotechnology companies, governments, associations, law firms, intellectual property agents and other companies to attend.Official registration and consultation channels:Contact：AnnPhone: 021-65650305Email：Marketing@zenseegroup.comhttp://en.zenseegroup.com/p/510934/ -
0926
Ivy Brain Tumor Center and BridgeBio Subsidiary QED Therapeutics Announce Collaboration to Advance Cancer Research and Treatment Options
The Ivy Brain Tumor Center at Barrow Neurological Institute, today announced a new collaboration with QED Therapeutics, Inc., a subsidiary of BridgeBio Pharma, Inc., (Nasdaq:BBIO) to investigate the FGFR1-3 tyrosine kinase inhibitor, infigratinib, for the treatment of glioblastoma (GBM). With the goal of addressing unmet medical needs for those affected by malignant brain cancer, this collaboration will focus on targeting FGFR (fibroblast growth factor receptor) genetic alterations that have been shown to spur growth in malignant tumors.“Five to seven percent of glioblastoma patients’ tumors are driven by FGFR signaling,” said Dr. Nader Sanai, director of the Ivy Brain Tumor Center. “We believe our collaboration with QED Therapeutics will enable us to test how FGFR-driven GBM tumors respond to infigratinib. If proven effective, we then intend to move forward new combined drug strategies incorporating this target.”In the preclinical studies, the Ivy Center will employ orthotopically implanted, well-characterized FGFR3 fusion patient-derived xenograft models. This is intended to allow the team to further explore the extent to which the drug crosses the blood-brain barrier and what activity it has in the brain.“We believe the work we are undertaking with the Ivy Center will provide critical insight to shape our clinical development strategy for this disease,“ said Susan Moran, M.D., M.S.C.E., chief medical officer of QED Therapeutics. “Our hope is that infigratinib will become the backbone of new combination therapies to treat patients with glioblastoma.”Infigratinib is an orally administered, FGFR1-3 selective tyrosine kinase inhibitor. QED Therapeutics has observed activity that appears to be meaningful in clinical trials for cancers that are driven by errors in the FGFR genes. These include chemotherapy-refractory cholangiocarcinoma with FGFR2 fusions and advanced urothelial carcinoma with FGFR3 genetic alterations.“The intricacies of the brain have posed significant challenges for brain cancer research and the development of therapies,” said Gary Li, head of translational medicine at QED Therapeutics. “We believe collaborating with the Ivy Brain Tumor Center will enable us to move swiftly and further translational research that we hope will unlock the doors to effective treatment options.”information source:pharma focus AsiaThe original link:https:https://www.pharmafocusasia.com/news/ivy-brain-tumor-center-and-bridgebio-subsidiary-qed-therapeutics-announce-collaboration-to-advance-cancer-research-and-treatment-options2019 Asia-pacific pharma IP Leader Summit:http://en.zenseegroup.com/p/510934/will be held in Beijing on November 14-15, and will attract more than 500 industry experts from domestic and foreign pharmaceutical companies, biotechnology companies, governments, associations, law firms, intellectual property agents and other companies to attend.Official registration and consultation channels:Contact：AnnPhone: 021-65650305Email：Marketing@zenseegroup.com/forms/view/22113/ -
0925
I-Mab Biopharma Announces Clinical Collaboration to Evaluate TJC4 in Combination with KEYTRUDA® (pembrolizumab)
I-Mab Biopharma ("I-Mab"), a China and U.S.-based clinical stage biopharmaceutical company exclusively focusing on the discovery and development of potential first-in-class and best-in-class biologics in immuno-oncology and autoimmune diseases, today announced that it has entered into a clinical research collaboration agreement with MSD, a tradename of Merck & Co., Inc., Kenilworth, NJ., USA, to evaluate the combination of I-Mab's TJC4 and MSD's anti-PD-1 therapy, KEYTRUDA® (pembrolizumab) in patients with multiple cancer types.Under this collaboration agreement, MSD will supply KEYTRUDA® (pembrolizumab) to I-Mab for use in clinical studies in combination with TJC4, a fully human anti-CD47 monoclonal antibody. Both parties will collaborate on a Phase 1 clinical trial, based on an agreed and finalized protocol, to evaluate the safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of TJC4 and KEYTRUDA® in patients with multiple cancer types."TJC4 is a highly differentiated anti-CD47 antibody currently under clinical development. This collaboration will provide an excellent opportunity to further explore therapeutic potential of combining TJC4 with KEYTRUDA® across different tumor types." said Dr. Jingwu Zang, Founder and Chairman of I-Mab.KEYTRUDA® is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.information source:pharma focus AsiaThe original link:https://www.pharmafocusasia.com/news/i-mab-biopharma-announces-clinical-collaboration-to-evaluate-tjc4-in-combination-with-keytruda2019 Asia-pacific pharma IP Leader Summit:http://en.zenseegroup.com/p/510934/ will be held in Beijing on November 14-15, and will attract more than 500 industry experts from domestic and foreign pharmaceutical companies, biotechnology companies, governments, associations, law firms, intellectual property agents and other companies to attend.Official registration and consultation channels:Contact：AnnPhone: 021-65650305Email：Marketing@zenseegroup.com/forms/view/22113/ -
0923
Boehringer Ingelheim Partners with Inflammasome Therapeutics to Develop Novel Therapies for Patients with Retinal Diseases
Boehringer Ingelheim and Inflammasome Therapeutics Inc. (Inflammasome) today announced they have entered into a co-development and license agreement to develop up to three therapies for patients with retinal diseases. By combining Inflammasome’s unique intravitreal (IVT) drug delivery technologies with Boehringer Ingelheim’s compounds from its retinal disease pipeline portfolio, Boehringer Ingelheim aims to develop novel therapies for retinal diseases.In 2019 there were an estimated 82 million patients in the seven key countries (U.S., Japan, Germany, U.K., Spain, Italy, France) affected by one of the three major forms of retinal disease: Age related macular degeneration (AMD), diabetic retinopathy (DR), and diabetic macular edema (DME). Globally, the prevalence rates of these and other retinal diseases are expected to increase over the next 10 years primarily due to aging populations and the global diabetes epidemic. Despite therapeutic advances in some disease areas during the past years, the real world results are poor, and there are no or only limited treatment options in many areas, resulting in an overall high unmet need. The collaboration between Boehringer Ingelheim and Inflammasome aims to address this challenge by using Inflammasome’s technology to deliver therapeutics in a biodegradable gel formulation into the eye.“We are delighted to enter into a collaboration with a company of Boehringer Ingelheim’s stature,” said Paul Ashton, Chief Executive Officer of Inflammasome Therapeutics. “We look forward to working with their team to leverage our respective technologies and expertise to develop new therapies for devastating retinal diseases leading to blindness. This collaboration fits our strategy of advancing the company via both collaborations and internal development.”“Boehringer Ingelheim is looking forward to developing Inflammasome’s novel technology for the delivery of our first-in- class retinal disease compounds working jointly with Inflammasome’s highly experienced scientific team,” said Clive R. Wood, PhD, Senior Corporate Vice President, Discovery Research at Boehringer Ingelheim. “This will enable us to develop a broad range of novel therapy options for the many patients with retinal diseases waiting urgently for better and new therapy options.”Boehringer Ingelheim takes a holistic approach in the development of novel retinal disease therapies, targeting key mechanisms in the pathogenesis of retinal diseases. The company has built a comprehensive pipeline portfolio of next generation therapy approaches in various stages of development up to Phase 2 in macular degeneration, diabetic retinal diseases and beyond. Inflammasome’s novel delivery technology using a long-acting degradable IVT implant complements this portfolio.Inflammasome is entitled to receive up to $160 million in up-front, research and development support and milestone gated development payments as well as tiered royalties based on future commercial sales of developed products and other milestones due on commercialization.information source:pharma focus AsiaThe original link:https://www.pharmafocusasia.com/news/boehringer-ingelheim-partners-with-inflammasome-therapeutics-to-develop-novel-therapies-for-patients-with-retinal-diseases2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p/510934/will be held in Beijing on November 14-15, and will attract more than 500 industry experts from domestic and foreign pharmaceutical companies, biotechnology companies, governments, associations, law firms, intellectual property agents and other companies to attend.Official registration and consultation channels:Contact：AnnPhone: 021-65650305Email：Marketing@zenseegroup.com/forms/view/22113/ -
0920
Clene Nanomedicine, Inc. Announces Selection of CNM-Au8 for the Harvard Led HEALEY ALS Platform Trial, a Clinical Trial for Amyotrophic Lateral Sclerosis
Clene Nanomedicine, Inc., a clinical-stage biopharmaceutical company, announced today that the Sean M. Healey & AMG Center for ALS at Mass General has selected CNM-Au8 for inclusion in the first ever Platform Trial for the treatment of amyotrophic lateral sclerosis (ALS).The Healey Center issued a call earlier this year for the best therapeutic candidates to apply for entry into the HEALEY ALS Platform Trial. They received responses from nearly 30 applicants across ten countries. Members from the Healey Center Science Advisory Committee, a group of renowned ALS scientists, chose the top five therapeutic candidates, including Clene's lead clinical asset, CNM-Au8. The selection of CNM-Au8 into the Healey ALS Platform Trial includes substantial financial support and provides access to over 50 expert ALS clinical trial sites across the United States."Our goal," said Merit Cudkowicz, MD, MSc, Director of the Healey Center, "is to lower the barriers for our pharma and academic colleagues to bring their exciting therapies for ALS forward to clinical trials. We are determined to accelerate therapy development for ALS."Important preclinical work supporting the effort with CNM-Au8 was performed in the laboratory of Nicholas J. Maragakis, Director of the ALS Center for Cell Therapy and Regeneration Research at Johns Hopkins, using human induced pluripotent stem cells from ALS patients. Dr. Maragakis is Chair of Clene's Scientific Advisory Board for ALS.Dr. Jonathan Glass, Professor of Neurology and Pathology at Emory University School of Medicine, as well as Director of the Emory ALS Center, remarked, "CNM-Au8 is quite an interesting compound that is ready for testing in ALS clinical trials. Its inclusion in the Platform Trial initiative is an excellent way to move forward for the development of CNM-Au8 as a potential therapeutic for ALS.""We are very pleased Clene's CNM-Au8 has been selected for participation in the Healey ALS Platform Trial. We believe the unique mechanism of CNM-Au8 represents a promising new approach for the treatment of neurodegenerative diseases, including ALS, with the potential for meaningful impact for the community of people diagnosed with this devastating and debilitating disease," said Rob Etherington, President and CEO of Clene. "We are continuing the development of CNM-Au8 in several clinical studies set to launch later this year."2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p/510934/will be held in Beijing on November 14-15, and will attract more than 500 industry experts from domestic and foreign pharmaceutical companies, biotechnology companies, governments, associations, law firms, intellectual property agents and other companies to attend.Official registration and consultation channels:Contact：AnnPhone: 021-65650305Email：Marketing@zenseegroup.com/forms/view/22113/
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